Innovative peptide-based products for companion animal health and infection prevention
Companion animals face many of the same antimicrobial resistance challenges as humans. Overuse of conventional antibiotics in veterinary medicine has led to resistant infections that are increasingly difficult to treat.
Amphoraxe is developing peptide-based solutions specifically formulated for companion animal health, offering effective treatment options that reduce the risk of resistance development while keeping our pets healthy.
Our top-performing peptides against each of the three primary canine ear infection pathogens.
S. aureus
Gram +Antibiotic Resistance Rates
P. aeruginosa
Gram −E. faecalis
Gram +Antibiotic Resistance Rates
Unlike conventional antibiotics that target specific molecular pathways, antimicrobial peptides disrupt bacterial membranes through physical interaction. This fundamental difference in mechanism is central to our research focus:
HC50 & CC50 values 30–70× above MIC in our experiments — wide safety margin for host cells
Membrane-targeting mechanism makes resistance evolution fundamentally difficult
Active against Gram-positive and Gram-negative pathogens — multiple candidates show cross-pathogen activity
Multi-peptide formulations enable broad-spectrum coverage
Bars represent relative potency (1/MIC) normalized to the most potent peptide per pathogen. MIC values are minimum inhibitory concentration (µg/mL) across all experiments conducted. E. faecalis is intrinsically resistant to cephalosporins, clindamycin, and aminoglycosides (as monotherapy) 7 — common vet antibiotics have no clinical activity against this pathogen.
Sources: 3 Mekic S et al. (2011). Vet Rec 169(5):125. PMID: 21742683 · 5 Azzariti S et al. (2022). Antibiotics 11(9):1204. PMC: 9494949 · 6 Kwon J et al. (2022). Vet Sci 9(11):592. PMC: 9695832 · 7 Hollenbeck BL, Rice LB (2012). Virulence 3(5):421-569. PMID: 23076243 · 9 KuKanich KS et al. (2022). J Vet Pharmacol Ther 45(5):454-462. PMID: 35698441
Interested in co-developing antimicrobial peptides for companion animal health?
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